Coulombe Lab

Research in our lab focuses on defining the properties and role of keratin intermediate filaments as they relate to homeostasis in complex epithelia. Keratin filaments are crucial determinants of the maintenance of cell and tissue integrity, as well as the response and adaptation to various stresses. Aberrations in their properties and/or regulation of keratin proteins are associated with monogenic diseases and polygenic traits such as cancer. We utilize a variety of approaches and assays in our research, ranging from biochemistry and cell and developmental biology to manipulating genes in vivo. {Originally Gold: October 12, 2017}