Baldridge Lab

We are interested in the basic mechanisms of protein quality control systems at cellular membranes. We study how these systems select their substrates, and aim to identify the cellular pathways regulated by them. These processes are important in pathologies related to cell stress, protein misfolding, and protein misregulation. Human illnesses linked to these problems include Parkinson’s disease, Alzheimer’s disease, and various cancers. Our longer-term goal is to understand how changing conditions in cells target substrate proteins to these integral-membrane quality control systems.