Cianfrocco Lab

The Cianfrocco Laboratory’s research program focuses on the structural biology and biophysics underlying microtubule-based intracellular transport. Overarching questions the lab is attempting to answer include: • How is specificity determined between motor proteins and cargo? • How are the activities of multi-motor complexes regulated? • What are the molecular consequences of neurodegenerative disease-causing mutations? The lab is approaching these questions from a number of different angles, using cryo-electron microscopy, single molecule TIRF, and biochemistry to relate protein structure to its activity in a cell. We are also developing cloud computing tools for cryo-electron microscopy to facilitate its adoption and to remove barriers for new users. {Previously Certified Gold: July 15, 2019}