Joglekar Lab

We study how eukaryotic cells achieve accurate genome inheritance during cell division. When a cell divides, it sends exactly one copy of its chromosomes to each daughter cell. This process, commonly referred to as chromosome segregation, is essential to all biology. It is also important for our well-being: chromosome missegregation plays a fundamental role in tumorigenesis and the emergence of drug resistance in cancer cells. It is implicated in age-related infertility. Therefore, it is essential that we fully understand the complex protein machinery that achieves accurate chromosome segregation.