Lopatin Lab

Current research in our laboratory revolves around the understanding the mechanisms of stress-induced remodeling of cardiac t-tubules. T-tubules are the central place for excitation contraction coupling, and disturbances in t-tubule structure and function are linked to numerous devastating cardiac disorders including heart failure. However, little is known about why and how t-tubular remodeling occurs during stress, and important details of the effects of disorganization of t-tubular system on various cellular functions remain to be investigated.