Ward Laboratory

Research in our lab focuses on the pathophysiology of experimental polymicrobial sepsis following cecal ligation and puncture. We are assessing the effects of complement activation, the roles of C5a and its receptors (C5aR, C5L2), and the roles of the IL-17 family of cytokines in the complications that follow, such as the cytokine storm, immunosuppression, and cardiac dysfunction. We are also involved in studying the mechanisms by which neutrophilis and macrophages are recruited into lung and activated, the role of proteases and oxidants in the induction of injury, the role of the complement system and C5a receptors, as well as the role of cytokines and chemokines. Furthermore, we also investigate the ability of the adrenergic system to regulate the lung inflammatory response. Accordingly, we have a wide scope of experience defining how the inflammatory response in lung is triggered and regulated.