Weinberg Lab

The Weinberg Laboratory is focused on understanding interactions between viruses and host immune responses. The overarching goals of our work are to define specific components of the immune system contribute to appropriate control of viral replication, to characterize virus-induced inflammatory responses that contribute to tissue damage and disease, and to define mechanisms by which persistent viral infections modulate host responses to subsequent unrelated challenges. We use mouse models and mouse pathogens to study viral pathogenesis, but our work has its roots in clinically relevant scenarios, such as defining differences in pathogenesis that are based on age or immunocompromise following bone marrow transplantation and considering effects of virus persistence on bacterial sepsis.